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Two cases diagnosed as Bronchiolitis Obliterans with Organizing Pneumonia (BOOP) by open lung biopsy are reported. The first was a 56-year-old man with cough, fever and hemoptesy for 7 months; while the second was a 60-year- old woman with cough, weakness and weight loss for 2 months which were not responding to the previous treatments. In P.A. chest roentgenograms, there were non-homogenic increases in density in bilateral middle bottom areas in both of the cases. While pneumonia treatment was given to the first case and tuberculosis treatment was given to the other, detailed investigations were done. And finally by open lung biopsy, both cases were diagnosed as BOOP and steroid treatment was given. The complaints of the second case relapsed, therefore the treatment was repeated. Two years after the treatment, a complete clinical-radiologic recovery was stabilized.