Thoracic Research and Practice
Clinical Study

The Incidence of Hepatitis C Virus in Patients With Lung Cancer

1.

Yüzüncü Yıl University, Medical Faculty, Department of Chest Diseases, Van, Turkey

2.

Yüzüncü Yıl University, Medical Faculty, Department of Medical Oncology, Van, Turkey

3.

Yüzüncü Yıl University, Medical Faculty, Department of Inf ection Diseases, Van, Turkey

Thorac Res Pract 2002; 3: Turkish Respiratory Journal 91-93
Keywords : lung cancer, HCV
Read: 575 Downloads: 288 Published: 08 October 2021

Background: Oncogenesis is a multifactorial process affected by environmental, genetic and infectious factors. A possible role of some specific viruses has been suggested in at least 15% of human cancer cases.

Objective: The aim of the study was to evaluate the frequency of HCV infection in patients with lung cancer and thus con­tribute to the documentation of a possible relationship between lung cancer and HCV infection.

Methods: Anti-HCV antibodies were measured in sera from 45 patients with lung cancer and in sera from 80 patients with benign lung diseases and 135 healthy individuals. A commercial enzyme linked immunosorbent kit assay was used in the analyses.

Results: Anti-HCV antibodies were positive in 6.7% of lung cancer patients while no anti-HCV antibody was detected in patients with benign lung diseases (p<0.05). In healthy con­trols, anti-HCV antibodies were positive in one subject (0.7 %). The histopathologic diagnosis of the 3 patients with pos­itive anti-HCV antibodies was non-small-cell cancer (squa­mous cell carcinoma in one case, adenocancer in the second, and adenosquamous cell carcinoma in the third patient). Hepatitis B surface antigen was present in 4 of the 45 patients with lung cancer and in 8 of the 80 benign lung disease cases (p>0.05).

Conclusions: The prevalence of anti-HCV positivity in patients with lung cancer was shown to be significantly higher than patients with benign lung disease and healthy individuals in our population. However, further studies which include a larger number of patients with HCV infection are needed to confirm this finding.

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