Thoracic Research and Practice
Original Article

Serum Vitamin D Is Inversely Associated with Blood Eosinophil Count Among Adults with Allergic Asthma


Department of Allergy and Immunology, Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, Guadalajara, México


University of Veracruzana, de Salud Pública Institute, Xalapa, México


Department of Internal Medicine, Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, Guadalajara, México


University of de Guadalajara Faculty of Health Sciences, Guadalajara, México

Thorac Res Pract 2023; 24: 208-213
DOI: 10.5152/ThoracResPract.2023.22154
Read: 1139 Downloads: 241 Published: 01 July 2023

OBJECTIVE: To evaluate the role that serum vitamin D concentration plays in the number of eosinophils in peripheral blood in adults with allergic asthma.

MATERIAL AND METHODS: A total of 142 patients were categorized based on different cutoff points for eosinophils: ≥200, ≥300, ≥400, and ≥500 cells/mL. The vitamin D concentration was stratified into <20 and ≥20 ng/mL. The association between vitamin D (independent variable) and eosinophils (dependent variable) was explored using multivariate analysis.

RESULTS: The average number of eosinophils in the included patients was 418 cells/mL, and 33.8% of the included patients had vita- min D concentrations ≥20 ng/mL. Asthmatic patients with vitamin D< 20 ng/mL had a higher mean concentration of eosinophils than did asthmatic patients with vitamin D ≥20 ng/mL (464 ± 377.7 eosinophils/mL vs. 327.8 ± 247.2 eosinophils/mL, P = .025). We also observed that vitamin D was inversely correlated with eosinophil count (rho = 0.244, P = .003). In the multivariate analysis, vitamin D <20 ng/mL showed a significant inverse association with each cutoff value for eosinophilia (odds ratio >1).

CONCLUSION: Vitamin D concentrations <20 ng/mL are associated with a significant increase in the number of eosinophils in blood. Studies that analyze the use of vitamin D supplements as complementary therapy for the treatment of asthma are needed.

Cite this article as: Hernández-Colín DD, Bedolla-Barajas M, Morales-Romero J, Robles-Figueroa M, Bedolla-Pulido A, del Rosario Arroyo-Sánchez N. Serum vitamin D is inversely associated with blood eosinophil count among adults with allergic asthma. Thorac Res Pract. 2023;24(4):208-213.

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