Thoracic Research and Practice
Clinical Study

Relation of Spirometry and Cytomorphological Changes Secondary to Cigarette Smoking

1.

Department of Pulmonology, SSK Süreyyapaşa Center for Chest Diseases and Thoracic Surgery, Istanbul, Turkey

2.

Department of Pathology, SSK Süreyyapaşa Center for Chest Diseases and Thoracic Surgery, Istanbul, Turkey

Thorac Res Pract 2000; 1: Turkish Respiratory Journal 21-25
Read: 653 Downloads: 382 Published: 06 October 2021

Objectives: The purpose of this study was to evaluate the relation between the changes of lung function parameters and sputum cytology among smokers and non-smokers with or without chronic obstructive pulmonary (COPD) and non- smoker healthy controls.

Patients: Sixty-nine male cases. Thirty-two smokers group (n=22 COPD, mean age ± SD, 59 ± 9 year-old, n=10 without COPD, mean age SD, 41 ± 5 year-old), twenty-nine ex smokers group (n=23 with COPD, mean age SD ± 61 ± 11 year-old, n=6 without COPD, mean age SD ±41 + 5 year- old), 8non-smokers healthy group (mean age SD ± 40 ± 7).

Intervention: Sputum processing and spirometry.

Measurement and Results: Spirometric measurements FEV1 and FEV1/FVC ratio were noted. Sputum processing and differential cell counts were performed by a blinded observer. We found that there was a negative correlation between was a negative correlation between FEV1/FVC ratio and pack-year cigarette smoking (r= - 0.66). In histological assessment, neutrophil counts were significantly increased in smokers and ex-smokers groups compared with the nonsmokers group (p<0.005). All groups revealed that there were significant differences in the number of macrophages, pigmented macrophages, neutrophils, mucous, mucous spirals, columnar epitheial cells (p< 0.001).

Conclusion: Cigarette smoking causes cellular changes after deterioration of lung function test as in natural causes of COPD. This clearly shows that smoking or its cessation is a powerful factor in determining the subjects’ outcome

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EISSN 2979-9139