Thoracic Research and Practice
Oral Presentation

Positive Airway Pressure Treatment Reduces Glycated Hemoglobin (HbA1c) Levels in Obstructive Sleep Apnea Patients: Longitudinal Data from the Esada

1.

Department of Chest Diseases, Ege University School of Medicine, İzmir, Turkey

2.

Sleep Disorders Center, Sahlgrenska University Hospital, and Center for Sleep and Wake Disorders, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

3.

Sleep Laboratory, ENT Department, Førde Central Hospital, Førde, Norway

4.

Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium

5.

Department of Respiratory Medicine, St Vincent´s University Hospital, Dublin, Ireland

6.

Sleep Disorders Centre, Hospital Antoine-Beclere, Clamart, France

7.

Department of Respiratory Medicine, P.J.Safarik University Hospital, Kosice, Slovakia

8.

DiBiMIS, University of Palermo, Palermo, Italy

9.

Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital and Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Finland

10.

Sleep Unit, Department of Pneumonology, Democritus University of Thrace, Alexandroupolis, Greece

Thorac Res Pract 2019; 20: Supplement 134-134
DOI: 10.5152/TurkThoracJ.2019.134
Read: 1383 Downloads: 687 Published: 01 August 2019

Objectives: Patients with obstructive sleep apnea (OSA) have an increased risk of developing metabolic disease such as diabetes mellitus. Positive airway pressure (PAP) therapy is the gold standard treatment for OSA. Although PAP can be a very effective therapy for OSA, the effects of such treatment on comorbidities such as type 2 diabetes mellitus (DM) is not sufficiently clarified. The objective of our study was to assess the effect of PAP treatment on the glycemic control in OSA patients.
 

Methods: Glycated hemoglobin (HbA1c) was assessed in patients of the European Sleep Apnea Database (ESADA) [n=1608, 13 centers, 74.2% males, mean age 53.9±10.8, body mass index (BMI) 32.8±7.0 and apnea hypopnea index (AHI) 40.4±24.5] at baseline and following PAP therapy (>90 days).
 

Results: Hb1Ac was reduced at follow-up from 5.98±1.01% to 5.93±0.98% (p=0.001, mean treatment duration 378.9±423.0 days). Subsequently, HbA1c decrease was more pronounced in diabetic patients (-0.152±1.022, p=0.019), severe OSA patients (-0.097±0.678, p=0.005), and morbidly obese patients (-0.1989±0.81446, p<0.001). HbA1c change was most pronounced in patients with weight reduction >5 kilos at follow-up (-0.379±0.988, p<0.001).
 

Conclusion: Overall HbA1c reduction with PAP therapy was limited. However, a clinically relevant HbA1c reduction was observed in severe OSA, in patients with DM, in obese patients and in combination with weight reduction.

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