The cause of localized right upper lobe edema in mitral regurgitation is the distribution of blood from left ventricle to superior pulmonary vein via left atrium. We present a 50-year-old male patient with right upper lobe pulmonary edema, having mitral stenosis in addition to mitral regurgitation, applied with the complaint of severe dyspnea, orthopnea and cough. Having no finding of infection, pulmonary edema localized in the lung resolved completely with cardiac glycosid and diuretic treatment in two days. There are many causes of pulmonary infiltration localized in the right upper lobe but one of rare cause is known or unknown mitral regurgitation and localized pulmonary edema is recovered well with diuretic therapy.