Thoracic Research and Practice
Clinical Study

Microvessel Density as a Marker of Tumor Angiogenesis in Nonsmall Cell Lung Cancer

1.

Associate Professor in the Department of Pathology, SSK Süreyyapaşa Chest and Cardiovascular Disease Hospital, Istanbul, Turkey

2.

Chief of the Department of Chest Surgery, SSK Süreyyapaşa Chest and Cardiovascular Disease Hospital, Istanbul, Turkey

Thorac Res Pract 2000; 1: Turkish Respiratory Journal 5-8
Read: 537 Downloads: 299 Published: 06 October 2021

Objective: To investigate the relation between microvessel density in surgical specimen and, histopathology and differentiation of tumor, nodal metastasis and stage of disease in patients with non-small cell lung carcinoma.

Design: Retrospective analysis of clinical and pathologic data abstracted from hospital charts.

Setting: Government referral-based research hospital. Patients: Twenty two epidermoid and 16 adenocarcinoma cases who underwent lung surgery.

Measurements: The microvessels in tumor specimens were demonstrated by staining endothelial cells immunohistoche- mically for factor VIII using streptoavidin-biotin, alkaline phosphatase complex technique.

Results: Microvessel counts were significantly higher in adenocarcinoma than in epidermoid carcinoma (p=0.0006). In poor differentiated epidermoid carcinoma specimens, angiogenesis was more intense than well and intermediate differentiated specimens (p=0.0064). Although the intensity of angiogenesis was high in patients with mediastinal lymph node metastasis when compared with non­metastasizing cases, the difference was not significant.

Conclusion: The intensity of angiogenesis is correlated with the grade of differentiation, the lower the differentiation the higher the angiogenesis, and is high in adeno-type of tumor.

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EISSN 2979-9139