Cisplatin and vepeside are reported as chemotherapeutic agents ca-using hypersensitivity reactions. However, severe bronchospasm le-ading to intubation and mechanical ventilation is uncommon. We report a 69-year-old woman who experienced severe bronchospasm after cisplatin-etoposide therapy. Bronchospasm did not resolve despite intensive medication and was relieved only after applicati¬on of invasive mechanical ventilation