Thoracic Research and Practice
Original Article

Lung involvement ön inflammatory Bowel Diseases

1.

Celal Bayar University, Pulmonology, Manisa, Turkey

2.

Memorial Hospital, Gastroenterology, Istanbul, Turkey

3.

Acıbadem Hastanesi, Gastroenterology, Istanbul, Turkey

4.

Department of Chest Diseases, Celal Bayar University School of Medicine, Manisa, Turkey

5.

Celal Bayar University, Pathology, Manisa, Turkey

6.

Celal Bayar University, Radiology, Manisa, Turkey

7.

Celal Bayar University Faculty of Medicine, Departments of Allergy and Immunology, Manisa, Turkey

8.

Celal Bayar University, Gastroenterology, Manisa, Turkey

9.

Department of Pulmonology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey

Thorac Res Pract 2007; 8: Turkish Respiratory Journal 1-9
Read: 628 Downloads: 425 Published: 14 October 2021

Aim: This study is aimed to evaluate the pulmonary involvement in in­flammatory bowel disease.

Material and methods: 17 cases (15 ulcer­ative colitis, 2 Crohn’s disease) were included. Respiratory symptoms, physical findings, pulmonary function tests, bronchial hyperreactivity, high resolution computed tomography (HRCT) of thorax, skin tests, serum IgE and eosinophil levels were evaluated. Bronchoscopy, bron­choalveolar lavage (BAL) and mucosal biopsy were performed in 15 cases.

Results: Mean age of 10 female (58.8%) 7 male (41.2%) cases was 41,0±12,5 year and the mean duration of disease was 5,6±5,9 year. 11 cases were in remission and 6 had active disease. Mean age in active group was lower than the remission group (36,10/43,72), while there was no difference in duration (5,2/6,3). 4 cases (23%) had symptoms like cough, dyspnea, wheezing. Pulmonary functions of the study group were in normal ranges except one. 15 cases (88,2%) had abnormal HRCT findings (air trapping, emphysema, peribronchial thickening, bronchiectasis, fibrosis, groung glass opacity, bullae). 7 cases (46,6%) had alveolitis in BAL. Biopsy specimens of 2 cases (11,8%) revealed submucosal inflammatory cell infiltration. These 2 cases had positive bronchial hyperreactivity (BHR) and skin tests also. No relation between disease activity with HRCT findings, BAL values and BHR was found.

Conclusion: Pulmonary involvement is frequently seen in IBD and may have various presentations. We did not find any correlation between the radiological and histological findings of the cases. A possible relationship may be masked as a result of the treatment and the small number of the study group. However, we sug­gest that pulmonary involvement should be evaluated in inflammatory bowel disease even in the absence of respiratory symptoms.

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EISSN 2979-9139