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Thoracic Research and Practice

25 243 2024

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Evidence Based Treatment of SARS-CoV2: A Narrative Review

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Original Article

Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot

Aylin Özgen Alpaydın ¹ , Tuba Yeter Turunç ² , Vildan Avkan-Oğuz ³ , Füsun Öner-Eyüboğlu ⁴ , Elif Tükenmez-Tigen ⁵ , İmran Hasanoğlu ⁶ , Güle Aydın ⁷ , Yasemin Tezer-Tekçe ⁸ , Seniha Şenbayrak ⁹ , Filiz Kızılateş ¹⁰ , Adalet Altunsoy Aypak ¹¹ , Sibel Altunışık-Toplu ¹² , Pınar Ergen ¹³ , Behice Kurtaran ¹⁴ , Meltem Işıkgöz Taşbakan ¹⁵ , Ayşegül Yıldırım ¹⁶ , Serkan Yıldız ¹⁷ , Kenan Çalışkan ¹⁸ , Ebru Ayvazoğlu ¹⁹ , Ender Dulundu ²⁰ , Ebru Şengül Şeref Parlak ²¹ , İrem Akdemir ⁷ , Melih Kara ²² , Sinan Türkkan ²³ , Kübra Demir-Önder ²⁴ , Ezgi Yenigün ²¹ , Aslı Turgut ²⁵ , Sabahat Alışır Ecder ²⁶ , Saime Paydaş ²⁷ , Tansu Yamazhan ¹⁵ , Tufan Egeli ²⁸ , Rüya Özelsancak ²⁹ , Arzu Velioğlu ³⁰ , Mehmet Kılıç ³¹ , Alpay Azap ⁷ , Erdal Yekeler ³² , Tuğrul Çakır ³³ , Yaşar Bayındır ¹² , Asiye Kanbay ³⁴ , Ferit Kuşcu ¹⁴ , Kemal Osman Memikoğlu ⁷ , Nazan Şen ³⁵ , Erhan Kabasakal ¹⁶ , Gülden Ersöz ³⁶

Author Affiliation(s)

1.

Department of Pulmonary Diseases, Dokuz Eylül University School of Medicine, İzmir, Turkey

2.

Department of Infectious Diseases and Clinical Microbiology, Başkent University Adana Teaching and Research Hospital, Adana, Turkey

3.

Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

4.

Department of Pulmonary Diseases, Başkent University Faculty of Medicine, Ankara, Turkey

5.

Department of Infectious Diseases and Clinical Microbiology, Marmara University Faculty of Medicine, İstanbul, Turkey

6.

Department of Infectious Diseases and Clinical Microbiology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Turkey

7.

Department of Infectious Diseases and Clinical Microbiology, Ankara University Faculty of Medicine, Ankara, Turkey

8.

Department of Infectious Diseases and Clinical Microbiology, Yüksek İhtisas Training and Research Hospital, Ankara City Hospital, Ankara, Turkey

9.

Department of Infectious Diseases and Clinical Microbiology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey

10.

Department of Infectious Diseases and Clinical Microbiology, Antalya Education and Research Hospital, Antalya, Turkey

11.

Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey

12.

Department of Infectious Diseases and Clinical Microbiology, İnönü University Faculty of Medicine, Malatya, Turkey

13.

Department of Infectious Diseases and Clinical Microbiology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey

14.

Department of Infectious Diseases and Clinical Microbiology, Çukurova University Faculty of Medicine, Adana, Turkey

15.

Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, İzmir, Turkey

16.

Department of Tuberculosis, Ministry of Health, General Directorate of Public Health, Ankara, Turkey

17.

Department of Nephrology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

18.

Department of General Surgery, Başkent University Adana Teaching and Research Hospital, Adana, Turkey

19.

Department of General Surgery, Başkent University Faculty of Medicine, Ankara, Turkey

20.

Department of General Surgery, Marmara University Faculty of Medicine, İstanbul, Turkey

21.

Department of Pulmonary Diseases, Ankara City Hospital, Ankara, Turkey

22.

Department of General Surgery, Health Science University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey

23.

Department of Pulmonary Surgery, Yüksek İhtisas Training and Research Hospital, Ankara, Turkey

24.

Department of Infectious Diseases and Clinical Microbiology, Health Science University Antalya Education and Research Hospital, Antalya, Turkey

25.

Department of Nephrology, İnönü University Faculty of Medicine, Malatya, Turkey

26.

Department of Nephrology, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey

27.

Department of Nephrology, Çukurova University Faculty of Medicine, Adana, Turkey

28.

Department of General Surgery, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

29.

Department of Nephrology, Başkent University, Adana Teaching and Research Hospital, Adana, Turkey

30.

Department of Nephrology, Marmara University Faculty of Medicine, İstanbul, Turkey

31.

Department of General Surgery, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey

32.

Department of Chest Surgery, Yüksek İhtisas Training and Research Hospital, Ankara, Turkey

33.

Department of General Surgery, Antalya Education and Research Hospital, Antalya, Turkey

34.

Department of Pulmonary Diseases, Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey

35.

Department of Pulmonary Diseases, Çukurova University Faculty of Medicine, Adana, Turkey

36.

Department of Infectious Diseases and Clinical Microbiology, Mersin University Faculty of Medicine, Mersin, Turkey

Thorac Res Pract 2024; 25: 130-135

DOI: 10.5152/ThoracResPract.2024.23110

Keywords : Solid organ transplantation, tuberculosis, latent tuberculosis infection, interferon-gamma release test, tuberculin skin test

Read: 1325 Downloads: 357 Published: 09 March 2024

Volume 25, Issue 3, May 2024

Previous Article

OBJECTIVE: Latent tuberculosis infection (LTBI) screening is strongly recommended in the pre-transplant evaluation of solid organ transplant (SOT) recipients, although it remains inadequate in many transplant centers. We decided to investigate pre-transplant TB risk assessment, LTBI treatment, and registry rates in Turkey.

MATERIAL AND METHODS: Adult SOT recipients who underwent tuberculin skin test (TST) and/or interferon-gamma release test (IGRA) from 14 centers between 2015 and 2019 were included in the study. An induration of ≥5 mm on TST and/or probable/positive IGRA (QuantiFERON-TB) was considered positive for LTBI. Demographic features, LTBI screening and treatment, and pre-/post-transplant TB history were recorded from the electronic database of transplantation units across the country and pooled at a single center for a unified database.

RESULTS: TST and/or IGRA were performed in 766 (33.8%) of 2266 screened patients most of whom were kidney transplant recipients (n = 485, 63.4%). LTBI screening test was positive in 359 (46.9%) patients, and isoniazid was given to 203 (56.5%) patients. Of the patients treated for LTBI, 112 (55.2%) were registered in the national registry, and 82 (73.2%) completed the treatment. Tuberculosis developed in 6 (1.06%) of 563 patients who were not offered LTBI treatment.

CONCLUSION: We determined that overall, only one-third of SOT recipients in our country were evaluated in terms of TB risk, only 1 of the 2 SOT recipients with LTBI received treatment, and half were registered. Therefore, we want to emphasize the critical importance of pretransplant TB risk stratification and registration, guided by revised national guidelines.

Cite this article as: Özgen Alpaydın A, Yeter Turunç T, Avkan-Oğuz V, et al. Latent tuberculosis infection management in solid organ transplantation recipients: A national snapshot. Thorac Res Pract. 2024;25(3):130-135.

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