Thoracic Research and Practice
Case report

Kikuchi-Fujimoto Disease in a Patient with Mediastinal Lymphadenopathy

1.

Department of Infectious Diseases and Clinical Microbiology, Başkent University Faculty of Medicine, Ankara, Turkey

2.

Department of Thoracic Surgery, Selçuk University Faculty of Medicine, Konya, Turkey

3.

Department of Chest Diseases and Tuberculosis, Başkent University Faculty of Medicine, Ankara, Turkey

Thorac Res Pract 2014; 15: 65-67
DOI: 10.5152/ttd.2014.38
Read: 1749 Downloads: 990 Published: 18 July 2019

Abstract

 

Kikuchi-Fujimoto disease is a benign self-limited syndrome with distinct histopathologic characteristics. Clinical symptoms include cervical lymphadenopathy with tenderness, fever of medium grade, night sweats, nausea, vomiting, and a sore throat. It is a rare disease worldwide. Diagnosis is based on histopathologic findings from an excisional lymph node biopsy. We present the case of a 37-year-old male patient with a fever of 15 days’ duration. Clinical examination revealed no other pathologic signs except for oral aphthous lesions and a fever of unknown origin. The patient’s fever did not resolve after 15 days’ follow-up, and the results of computed tomographic study of the thorax revealed several sites of mediastinal lymphadenopathy. The diagnosis of Kikuchi-Fujimoto disease (histiocytic necrotising lymphadenitis) was based on the results of pathologic examination of the biopsy specimen. The patient’s signs and symptoms resolved without antibiotic therapy. This case report of a patient with a fever of unknown origin is presented because of the rare involvement of mediastinal lymphadenopathy without cervical lymphadenopathy. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of the patient who presents with fever and mediastinal lymphadenopathy.
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