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Original Article

Impact of Non-surgical Periodontal Therapy on Pulmonary functions, Periodontal Health and Salivary Matrix Metalloproteinase-8 of COPD Patients with Chronic Periodontitis: A Clinico-biochemical Study

Sakshi Sharma 1 , Abhaya Gupta 1 , Ajay Kumar Verma 2 , Anjani Pathak 1 , Sheetal Verma 3 , Shyam Chand Chaudhary 4 , Shalini Kaushal 1 , Nand Lal 1 , Surya Kant 2 , Umesh Pratap Verma 1
1.

Department of Periodontology, King George’s Medical University, Faculty of Dental Sciences, Lucknow, Uttar Pradesh, India

2.

Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India

3.

Department of Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, India

4.

Department of Internal Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India

Thorac Res Pract 2021; 22: 324-332
DOI: 10.5152/TurkThoracJ.2021.20096
Keywords : Chronic periodontitis, chronic obstructive pulmonary disease, non-surgical periodontal therapy, matrix metalloproteinases-8
Read: 1325 Downloads: 890 Published: 01 July 2021
Volume 22, Issue 4, July 2021
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Objective: The aim of the study was to assess the impact of non-surgical periodontal therapy (NSPT) on periodontal clinical parameters, spirometric indices, and salivary MMP-8 levels in patients with chronic obstructive pulmonary disease (COPD) with concurrence of chronic periodontitis (CP) compared with systemically healthy CP.

MATERIAL AND METHODS: In this prospective clinico-biochemical study, a total of 75 patients belonging to various socioeconomic strata were randomly divided into cases, that is, COPD patients as per the Global Initiative for Obstructive Lung Disease (GOLD) criteria with concurrence of CP [at least ≥ 20 teeth with ≥ 2 tooth sites having pocket probing depth (PPD) or clinical attachment loss (CAL) ≥ 4mm and bleeding on probing (BOP)] and controls (systemically healthy CP). Both groups underwent NSPT and were evaluated for plaque index (PI), gingival index (GI), PPD, CAL, and BOP and spirometry (FEV1/forced vital capacity (FVC)) values at baseline, 3, 6, and 12 months and for salivary MMP-8 levels at baseline and 3 months.

Results: Statistical results showed that cases (COPD with CP; n = 37) were significantly older (mean age 56.16 ± 9.01 years), ex-smokers (48.6%) with male preponderance (78.4%), and belonged to the upper middle class (40.5%) as compared to controls (systemically healthy CP; n = 38). After NSPT, significant improvement in mean PI, GI, PPD, CAL, and BOP was observed in both groups at 3, 6, and 12 months with better results in controls. FEV1/FVC was significantly improved (P < .001) in cases with insignificant change in controls at 12 months. After 3 months, MMP-8 levels were significantly reduced in cases (P = .002) and controls (P < .001).

Conclusion: The present study provided substantial evidence that COPD patients have poorer periodontal health as compared to systemically healthy counterparts. Further, these patients showed improvement in FEV1/FVC, however, with higher salivary MMP-8 levels despite NSPT at the end of the study, indicating a possible role of systemic inflammatory overburden of pulmonary disease. 

Cite this article as: Sharma S, Gupta A, Kumar Verma A, et al. Impact of non-surgical periodontal therapy on pulmonary functions, periodontal health and salivary matrix metalloproteinase-8 of COPD patients with chronic periodontitis: A clinico-biochemical study. Turk Thorac J. 2021; 22(4): 324-332.224

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