Thrombophilic risk factors are accused in the pathogenesis of venous thromboembolism. Recently high levels of factor IX have been shown to increase the risk of deep venous thrombosis. We experienced a case of pulmonary thromboembolism (PTE), who had no risk factors for venous thromboembolism and was evaluated for inherited thrombophilic risk factors. She had normal Factor VIII level and no transition in the prothrombin gene but she was found to have high level of factor IX (173 lU/dl) and Factor V 1691 G-A mutation. The patient was carrying two different thrombotic risk factors that were not reported before for the cause of PTE. The genetic basis of coagulopaty should be determined in all PTE patients without a significant risk factor..