Thoracic Research and Practice
Case report

High Factor IX Level With a Factor V 1691 G-A Mutation in a Case of Pulmonary Thromboembolism

1.

Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey

2.

Department of Pediatric Molecular Genetics, Ankara University School of Medicine, Ankara, Turkey

3.

Department of Pulmonary Medicine, Başkent University School of Medicine, Adana Hospital, Adana, Turkey

Thorac Res Pract 2004; 5: Turkish Respiratory Journal 49-51
Read: 587 Downloads: 395 Published: 11 October 2021

Thrombophilic risk factors are accused in the pathogenesis of venous thromboembolism. Recently high levels of factor IX ha­ve been shown to increase the risk of deep venous thrombosis. We experienced a case of pulmonary thromboembolism (PTE), who had no risk factors for venous thromboembolism and was evaluated for inherited thrombophilic risk factors. She had nor­mal Factor VIII level and no transition in the prothrombin ge­ne but she was found to have high level of factor IX (173 lU/dl) and Factor V 1691 G-A mutation. The patient was carrying two different thrombotic risk factors that were not reported before for the cause of PTE. The gene­tic basis of coagulopaty should be determined in all PTE pati­ents without a significant risk factor..

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EISSN 2979-9139