Thoracic Research and Practice
Original Article

Effect of Nasal Continuous Positive Airway Pressure Therapy on the Functional Respiratory Parameters and Cardiopulmonary Exercise Test in Obstructive Sleep Apnea Syndrome

1.

Department of Chest Diseases, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

2.

Department of Neurology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

3.

Department of Physiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

4.

Department of Public Health, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

Thorac Res Pract 2016; 17: 1-6
DOI: 10.5578/ttj.17.1.001
Read: 1885 Downloads: 1127 Published: 18 July 2019

Abstract

OBJECTIVES: Nasal continuous positive airway pressure (nCPAP) treatment is the gold standard treatment for obstructive sleep apnea syndrome (OSAS). In this study, we aimed to show that the pulmonary functions, exercise limitation on the cardiopulmonary exercise test (CPET), and the health-related quality of life can be improved after a short treatment period by nCPAP.

 

MATERIALS AND METHODS: Our case group with severe obstructive sleep apnea (OSA) performed incremental CPET before and after 8 weeks of nCPAP treatment. All the subjects also underwent physical examination, body composition analysis, simple spirometric measurements, maximal inspiratory pressure (PImax)-maximal expiratory pressure (PEmax), and lung volume tests before and after nCPAP treatment.

 

RESULTS: Thirty-one patients (4 female, 27 male) completed the study. The mean age of the patients was 53.41 ± 1.46 years. Sixteen had at least one comorbidity. In addition, 17 of the subjects were ex-smokers. After nCPAP treatment for 8 weeks, higher PImax-PEmax (p< 0.05), peak oxygen uptake (p= 0.001), workpeak (p= 0.000), maximal heart rates (p= 0.000), and short form-36 scores (p< 0.05) were observed. nCPAP treatment helped control the blood pressure (p= 0.005). There was no significant change in body composition analysis, spirometric parameters, and lung volumes.

 

CONCLUSION: In a short time period, nCPAP can improve exercise capacity, respiratory muscle strength, and the health-related quality of life scores and help control blood pressure.

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