Continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea syndrome (OSAS) is an efficient method. Epworth Sleepiness Scale and a standard questionnaire were applied to 23 cases (mean age: 57.6±10.7 years; 17 (73.9%) male, 6 (26.1%) female) diagnosed as OSAS with full polysomnography who were prescribed to use CPAP between May 1999 and January 2001. Mean body mass index (BMI) was 3O.7±5.9 kg/m2 in males and 34.4+8.9 kg/m2 in females, mean apne-hypopnea index (AHI) was 48.9±24-1 and mean duration of CPAP therapy was 234.2±212.6 days (18-810). Fourteen (60.8%) patients were using CPAP for > 6 hours a night in seven days a week. The most common side effect was hyperaemia and erosion of the nose. Dryness of the eyes and upper airways, awaking at night and noise associated with CPAP were more rare complaints. Mean score of Epworth Sleepiness Scale before CPAP therapy was 15.1 ±5.1 and after therapy it was 5.5±4.6. The difference was statistically significant (p=0.000). No statistical significant correlation was detected between the score after CPAP usage and the duration of CPAP therapy (p=0.274). Symptoms like snoring daytime sleepiness and witnessed apnea were found to be significantly decreased. In conclusion, although side effects predominantly associated with nasal masks limit usage in patients using CPAP, subjective improvement in symptoms is a factor increasing patient compliance.