A case of bronchial leiomyoma arising from right middle lobe bronchus in a 44-year-old non-smoker woman with symptoms of cough and hemoptysis was presented. Bronchoscopy revealed complete obliteration of middle lobe bronchus by a soft tissue mass. Although an inferior bilobectomy was technically feasible, pneumonectomy was performed due to the small size of upper lobe, which was not expected to be fully expanded. The patient was discharged without any complications postoperatively. A well-demarcated lesion composed of spindle-shaped cells that showed reactivity for alpha-smooth muscle actin, desmin, and vimentin was observed. The patient was medically well 2 years after the operation.