A 44-year-old patient with CRF, with findings indicating that TB can mimic any other disorder in chronic renal failure including bronchial carcinoma, is presented. The patient was admitted with fever of unknown origin. Chest X-ray revealed left hilar enlargement. Computerized tomography (CT) of the thorax confirmed a mediastinal mass surrounding the large vessels. Fiberoptic bronchoscopic findings suggested malignancy, but the histopathological diagnosis was TB. The mass showed regression with appropriate anti-TB therapy. Chronic renal failure (CRF) is a condition that increases susceptibility to tuberculosis (TB) and predisposes to atypical presentations. Great caution must be observed in interpreting CT and bronchoscopic findings in patients with CRF.