We report a patient with pleural epithelial type mesothelioma who presented with metastasis to axillary lymph nodes. Pathology also revealed findings consistent with tuberculous lymphadenitis.A 47-year-old man presented with chest pain, dyspnea and a history of asbestos exposure, and on physical examination a 2 cm lymph node in the right axilla and a 1 cm lymph node in the left supraclavicular area were detected. The lesions were hard in consistency, moveable and tender. Excisional biopsies were performed to both sets of lymph nodes and a transthoracic fine needle aspiration biopsy was performed to the extensive mass in the right hemitorax. Morphological, immunohistochemical, and ultrastructural findings of both biopsies revealed malignant mesothelioma. Histological examination of the left supraclavicular lymph node biopsy specimen showed a granulomatous lesion with caseation, a finding consistent with a tuberculous infection.We believe this is the first reported case of pleural epithelial type mesothelioma with metastasis to axillary lymph nodes which is also associated with tuberculous lymphadenitis.