Investigation of Susceptibility in Mycobacterium tuberculosis Isolates to Amoxycillin-Clavulanate by Using E-Test
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Original Article

Investigation of Susceptibility in Mycobacterium tuberculosis Isolates to Amoxycillin-Clavulanate by Using E-Test

Thorac Res Pract 2000;1(2):28-31
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Abstract

Abstract

In vitro susceptibility of 40 Mycobacterium tuberculosis isolates to amoxycillin-clavulanate, which were isolated from various clinical specimens and 33 of which were susceptible to first line-drugs and 7 of resistant to more than one antimycobacterial agents were investigated by using E-test. It was determinated that MIC50 and MIC90 values of amoxycillin-clavulanate for susceptible strains were 8 mg/ml and 96 mg/ml, respectively. These values in multiple-drug resistant M. tuberculosis isolates were found as 48 mg/ml and 256 mg/ml, respectively. According to the results of our study, amoxycillin-clavulanate combination has effective antimycobacterial activity especially against the susceptible strains.

Keywords: Mycobacterium tuberculosis, amoxycillin-clavulanate, E-test